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pentobarbital will minimize the level or result of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Steer clear of coadministration of lefamulin with strong or average CYP3A inducers Until the gain outweighs pitfalls. Monitor for lowered efficacy.pentobarbital will lower the level or result o